Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2001 1
2003 1
2007 1
2009 2
2010 3
2011 2
2012 2
2014 1
2015 1
2016 2
2017 3
2018 1
2019 1
2021 1
2023 2
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

23 results

Results by year

Filters applied: . Clear all
Page 1
Deletion of Endothelial TRPV4 Protects Heart From Pressure Overload-Induced Hypertrophy.
Adapala RK, Katari V, Kanugula AK, Ohanyan V, Paruchuri S, Thodeti CK. Adapala RK, et al. Hypertension. 2023 Nov;80(11):2345-2356. doi: 10.1161/HYPERTENSIONAHA.123.21528. Epub 2023 Sep 13. Hypertension. 2023. PMID: 37702061 Free article.
RESULTS: We demonstrate that endothelial-specific deletion of TRPV4 preserved cardiac function, cardiomyocyte structure, and reduced cardiac fibrosis compared with TRPV4(lox/lox) mice, 28 days post-transverse aortic constriction. Interestingly, comprehensive RNA seq …
RESULTS: We demonstrate that endothelial-specific deletion of TRPV4 preserved cardiac function, cardiomyocyte structure, and reduced cardiac …
RNA sequencing analysis of FGF2-responsive transcriptome in skin fibroblasts.
Wu B, Tang X, Zhou Z, Ke H, Tang S, Ke R. Wu B, et al. PeerJ. 2021 Jan 15;9:e10671. doi: 10.7717/peerj.10671. eCollection 2021. PeerJ. 2021. PMID: 33520460 Free PMC article.
BACKGROUND: Fibroblast growth factor 2 (FGF2) is a highly pleiotropic cytokine with antifibrotic activity in wound healing. ...They were mainly involved in ECM-receptor interaction, PI3K-Akt signaling, and the Hippo pathway. The hub DEGs include …
BACKGROUND: Fibroblast growth factor 2 (FGF2) is a highly pleiotropic cytokine with antifibrotic activity …
Lysyl oxidase propeptide promotes adipogenesis through inhibition of FGF-2 signaling.
Griner JD, Rogers CJ, Zhu MJ, Du M. Griner JD, et al. Adipocyte. 2017 Jan 2;6(1):12-19. doi: 10.1080/21623945.2016.1271511. Epub 2016 Dec 14. Adipocyte. 2017. PMID: 28452589 Free PMC article.
LOX is synthesized as an inactive 50 kD pre-proenzyme, and secreted to the extracellular matrix where it is cleaved into an active 32 kD LOX, and an 18kD free propeptide (LOX-PP), purportedly an inhibitor of fibroblast growth factor-2 …
LOX is synthesized as an inactive 50 kD pre-proenzyme, and secreted to the extracellular matrix where it is cleaved into an active 32 …
Spatiotemporal gene targeting in the mouse corneal endothelium.
Lee J, Heur M. Lee J, et al. Taiwan J Ophthalmol. 2023 Jan 11;13(1):28-33. doi: 10.4103/tjo.TJO-D-22-00125. eCollection 2023 Jan-Mar. Taiwan J Ophthalmol. 2023. PMID: 37252171 Free PMC article.
RESULTS: Following Cre-mediated targeting of Zeb1 by intracameral 4-OHT injection in Zeb1(flox/flox): UBC-CreERT2 mice, FGF2 treatment in ex vivo organ culture resulted in abrogation of Zeb1 mRNA and protein expression in the corneal endothelium. ...These results suggest t …
RESULTS: Following Cre-mediated targeting of Zeb1 by intracameral 4-OHT injection in Zeb1(flox/flox): UBC-CreERT2 mice, FGF2 treatmen …
Lysyl oxidase propeptide inhibits FGF-2-induced signaling and proliferation of osteoblasts.
Vora SR, Palamakumbura AH, Mitsi M, Guo Y, Pischon N, Nugent MA, Trackman PC. Vora SR, et al. J Biol Chem. 2010 Mar 5;285(10):7384-93. doi: 10.1074/jbc.M109.033597. Epub 2010 Jan 4. J Biol Chem. 2010. PMID: 20048148 Free PMC article.
Pro-lysyl oxidase is secreted as a 50-kDa proenzyme and is then cleaved to a 30-kDa mature enzyme (lysyl oxidase (LOX)) and an 18-kDa propeptide (lysyl oxidase propeptide (LOX-PP)). The presence of LOX-PP in the cell layers of phenotypically normal osteoblast …
Pro-lysyl oxidase is secreted as a 50-kDa proenzyme and is then cleaved to a 30-kDa mature enzyme (lysyl oxidase (LOX)) and an 18-kDa …
In vitro reversion of activated primary human hepatic stellate cells.
El Taghdouini A, Najimi M, Sancho-Bru P, Sokal E, van Grunsven LA. El Taghdouini A, et al. Fibrogenesis Tissue Repair. 2015 Aug 6;8:14. doi: 10.1186/s13069-015-0031-z. eCollection 2015. Fibrogenesis Tissue Repair. 2015. PMID: 26251672 Free PMC article.
The aim of the present study is to identify experimental conditions that can revert the in vitro activated phenotype of primary human HSCs and consequently to map the molecular events associated with this reversion process by gene expression profiling. RESULTS: We find that epide …
The aim of the present study is to identify experimental conditions that can revert the in vitro activated phenotype of primary human HSCs a …
An integrative approach predicted co-expression sub-networks regulating properties of stem cells and differentiation.
Sahu M, Mallick B. Sahu M, et al. Comput Biol Chem. 2016 Oct;64:250-262. doi: 10.1016/j.compbiolchem.2016.07.006. Epub 2016 Jul 18. Comput Biol Chem. 2016. PMID: 27475236
From the pathway analysis of sub-networks of hESCs-EBs, we hypothesize that FGF2 is contributing to pluripotent transcription network of hESCs in association with DNMT3B and JARID2 thereby facilitating cell proliferation. On the contrary, FGF2 is found to promote ce …
From the pathway analysis of sub-networks of hESCs-EBs, we hypothesize that FGF2 is contributing to pluripotent transcription network …
Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis.
Lu J, Yang JH, Burns AR, Chen HH, Tang D, Walterscheid JP, Suzuki S, Yang CY, Sawamura T, Chen CH. Lu J, et al. Circ Res. 2009 Mar 13;104(5):619-27. doi: 10.1161/CIRCRESAHA.108.190116. Epub 2009 Jan 15. Circ Res. 2009. PMID: 19150883
Hypercholesterolemic (LDL-cholesterol, >160 mg/dL) human LDL was fractionated into L1-L5, increasingly electronegative, by ion-exchange chromatography. In cultured bovine aortic ECs (BAECs), L5 upregulated LOX-1 and induced apoptosis. Transfection of BAECs with LOX …
Hypercholesterolemic (LDL-cholesterol, >160 mg/dL) human LDL was fractionated into L1-L5, increasingly electronegative, by ion-exchange c …
Identification of differentiation-stage specific markers that define the ex vivo osteoblastic phenotype.
Twine NA, Chen L, Pang CN, Wilkins MR, Kassem M. Twine NA, et al. Bone. 2014 Oct;67:23-32. doi: 10.1016/j.bone.2014.06.027. Epub 2014 Jun 28. Bone. 2014. PMID: 24984278
Hierarchical clustering and Pearson's correlation generated 4 groups of genes: early stage differentiation genes (peak expression: 0-24h, n=28) which were enriched for extracellular matrix organisation, e.g. COL1A1, LOX, and SERPINH1; middle stage differentiating genes (pe …
Hierarchical clustering and Pearson's correlation generated 4 groups of genes: early stage differentiation genes (peak expression: 0-24h, n= …
Regulation of elastin promoter by lysyl oxidase and growth factors: cross control of lysyl oxidase on TGF-beta1 effects.
Oleggini R, Gastaldo N, Di Donato A. Oleggini R, et al. Matrix Biol. 2007 Jul;26(6):494-505. doi: 10.1016/j.matbio.2007.02.003. Epub 2007 Feb 27. Matrix Biol. 2007. PMID: 17395448
Most were affected by both LOX and TGF-beta1, while on some only TGF-beta1 was effective. LOX presence mostly inhibited the TGF-regulated complexes. ...Two more restricted regions binding AP1 and SMAD were identified as mediators of LOX effects and of LOX …
Most were affected by both LOX and TGF-beta1, while on some only TGF-beta1 was effective. LOX presence mostly inhibited the TG …
23 results